“Target-Site” Drug Metabolism and Transport

Epigenetic regulation of drug metabolism and transport

The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug-metabolizing enzyme genes has emerged as an important mechanism. Epigenetic regulation refers to heritable factors of genomic modifications ...

valproate adverse effects on creatine metabolism and transport in a patient under drug therapy.

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Soy isoflavonoids and cancer -- metabolism at the target site.

Isoflavonoids are members of the broad class of plant polyphenols that have been shown in vivo to have benefit in the prevention of a wide variety of chronic diseases, including cancer. For genistein (5,7,4'-trihydroxyisoflavone) (GEN), the major isoflavone in soy, reported mechanisms for these biological activities are numerous and include regulation of estrogen-mediated events, inhibition of ...

Drug Transport and Metabolism in Rat and Human Intestine

Drug Transport and Metabolism in the Blood–Brain Barrier

Despite recent advances, the treatment of brain diseases and neurological disorders, such as the Parkinson and Alzheimer syndromes, multiple sclerosis, brain cancer, psychiatric disorders, many forms of epilepsy, chronic pain, and migraine, remains a major challenge. There is a growing need for the development of effective CNS-active drugs that are able to reach the desired regions of the brain...